pentobarbital will decrease the extent or effect of parecoxib by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Observe.
pentobarbital decreases results of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of CYP3A4 inducers might reduce sufentanil ranges and efficacy, perhaps precipitating withdrawal syndrome in sufferers who may have designed physical dependence to sufentanil. Discontinuation of concomitantly utilised CYP3A4 inducers could maximize sufentanil plasma concentration.
pentobarbital will lower the level or impact of colchicine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will lower the extent or impact of lapatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
fentanyl transmucosal and pentobarbital both boost sedation. Stay away from or Use Alternate Drug. Limit use to clients for whom choice cure possibilities are insufficient
pentobarbital will lower the extent or outcome of quetiapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will reduce the extent or impact of indinavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will decrease the extent or outcome of rolapitant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Extended-expression coadministration of robust CYP3A4 inducers with rolapitant may perhaps drastically minimize rolapitant efficacy.
pentobarbital will lessen the level or result of estropipate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital decreases levels of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Steer clear of Unless of course the coadministration outweighs the possible threat of ponatinib underexposure; keep track of for indications of reduced efficacy.
pentobarbital will minimize the level or influence of atazanavir by affecting hepatic/intestinal check here enzyme CYP3A4 metabolism. Small/Importance Not known.
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Animal info. Phenobarbital sodium is carcinogenic in mice and rats right after lifetime administration. In mice, it made benign and malignant liver cell tumors. In rats, benign liver cell tumors were being noticed incredibly late in life.
No sufficient very well-managed scientific studies are actually performed in pediatric sufferers; however, safety and efficiency of pentobarbital in pediatric sufferers is supported by various research and scenario stories cited during the literature.