pentobarbital will decrease the extent or effect of parecoxib by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Observe.pentobarbital decreases results of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of CYP3A4 inducers might reduce sufentanil ranges and ef